In this phenomenon-driven activity, students investigate how cells are signaled to make melanin and explain how mutations in melanin pathway proteins affect the coat color of various organisms.
In this activity, students interpret several pedigrees of autosomal dominant and recessive conditions and consider the benefits and limitations of genetic testing.
This activity guides the analysis of a published scientific figure from a study that explored inbreeding depression in a small, isolated population of wolves.
This video presents an intriguing phenomenon: two patients who carry the same genetic variation, which is known to cause sickle cell disease, have very different outcomes.
This activity builds on information presented in the short film Genes as Medicine. Students interpret actual pedigrees to determine the inheritance pattern of Leber congenital amaurosis (LCA), an inherited form of blindness. They also examine protein sequence data to explore mutations that can cause LCA.
This activity explores an image of tattoo ink particles inside cells, which serves as a phenomenon for learning about the structure and color of human skin.
This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.
This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.
This film describes the scientific principles and the research efforts involved in the development of a gene therapy for a congenital form of blindness, and how a young patient benefited from this medical breakthrough.