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Inheritance and Mutations in a Single-Gene Disorder

This activity builds on information presented in the short film Genes as Medicine. Students interpret actual pedigrees to determine the inheritance pattern of Leber congenital amaurosis (LCA), an inherited form of blindness.

Activity for Genes as Medicine

This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.

Cell Division and Cancer Risk

This activity guides the analysis of a published scientific figure from a study that investigated how random mutations during cell division can contribute to cancer.

DNA Profiling Activity

This multipart activity is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world.

Understanding Variation in Human Skin Color

In this activity, students extend the concepts covered in the short film The Biology of Skin Color through the application of models and mathematical thinking to explain how genomic variation and human ancestry can explain differences in skin color, a polygenic trait.

The Teosinte Hypothesis

In this activity, students further explore the short film Popped Secret: The Mysterious Origin of Corn, by working through the mathematical concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize.

Lactose Intolerance: Fact or Fiction

In this activity, students evaluate and discuss statements about the evolutionary relationship between milk consumption and lactose tolerance discussed in the short film Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture.

Pedigrees and the Inheritance of Lactose Intolerance

In this activity, students explore concepts covered in the short film Got Lactase? The Co-evolution of Genes and Culture about the genetic variations associated with lactose tolerance/intolerance and how the trait is inherited in families.

Milk: How Sweet Is It?

In this activity, students simulate a lactose tolerance test, similar to the one shown in the short film The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture, to determine which samples contain the lactase enzyme.