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In this activity, students interpret several pedigrees of autosomal dominant and recessive conditions and consider the benefits and limitations of genetic testing.

In this inquiry-based activity, students engage in science practices to figure out why some people with a genetic condition that usually leads to sickle cell disease do not have disease symptoms.
 

This video case study explores the approaches scientists used to identify a mutation that causes retinitis pigmentosa (RP), a progressive disease that leads to blindness.

This activity builds on information presented in the short film Genes as Medicine. Students interpret actual pedigrees to determine the inheritance pattern of Leber congenital amaurosis (LCA), an inherited form of blindness. They also examine protein sequence data to explore mutations that can cause LCA.

This activity explores an image of tumor cells invading muscle tissue, which serves as a phenomenon for learning about cancer, mutations, and cell division.

This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research.

In this hands-on activity, students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat different genetic conditions. The activity reinforces concepts covered in the Click & Learn “Central Dogma and Genetic Medicine.”

This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.

This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions.

This activity guides the analysis of a published scientific figure from a study that investigated how random mutations during cell division can contribute to cancer.

This interactive module explores how mutations arise in germline and somatic cells. It also shows how these mutations can lead to genetic conditions, such as cystic fibrosis and cancer.

This interactive module allows students to examine evidence from brain anatomy, tissue histology, and genetic studies to identify possible targets for the treatment of Alzheimer’s disease.