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Inheritance and Mutations in a Single-Gene Disorder

This activity builds on information presented in the short film Genes as Medicine. Students interpret actual pedigrees to determine the inheritance pattern of Leber congenital amaurosis (LCA), an inherited form of blindness.

“Fixing” Gene Expression

In this hands-on activity, students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat different genetic conditions. The activity reinforces concepts covered in the Click & Learn “Central Dogma and Genetic Medicine.”

Activity for Genes as Medicine

This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.

Genes as Medicine

This film describes the scientific principles and the research efforts involved in the development of a gene therapy for a congenital form of blindness, and how a young patient benefited from this medical breakthrough.

Epidemiology of Nipah Virus

This activity complements the video Virus Hunter: Monitoring Nipah Virus in Bat Populations. Students explore cases of Nipah virus infection, analyze evidence, and make calculations and predictions based on data.

Central Dogma and Genetic Medicine

This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions.

Viral Lysis and Budding

This activity outlines two demonstrations that model how enveloped and nonenveloped viruses are released from infected cells.

HIV Receptors and Co-receptors

This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

Viral DNA Integration

In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

HIV Protease Inhibitors

This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.