In this inquiry-based activity, students engage in science practices to figure out why some people with a genetic condition that usually leads to sickle cell disease do not have disease symptoms.
This video presents an intriguing phenomenon: two patients who carry the same genetic variation, which is known to cause sickle cell disease, have very different outcomes.
This activity explores an image of tumor cells invading muscle tissue, which serves as a phenomenon for learning about cancer, mutations, and cell division.
In this hands-on activity, students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat different genetic conditions. The activity reinforces concepts covered in the Click & Learn “Central Dogma and Genetic Medicine.”
This activity explores the content and research presented in the short film Genes as Medicine, which tells the story of how scientists succeeded in developing a gene therapy for a type of congenital blindness.
This film describes the scientific principles and the research efforts involved in the development of a gene therapy for a congenital form of blindness, and how a young patient benefited from this medical breakthrough.
This interactive module uses the central dogma as a model for exploring how modern molecular biology technologies can be used to treat different genetic conditions.
This interactive module explores how mutations arise in germline and somatic cells. It also shows how these mutations can lead to genetic conditions, such as cystic fibrosis and cancer.
This activity guides the analysis of a published scientific figure from a study that tested a new treatment for chronic myeloid leukemia (CML), a cancer of white blood cells.
This interactive module explores the phases, checkpoints, and protein regulators of the cell cycle. The module also shows how mutations in genes that encode cell cycle regulators can lead to the development of cancer.
This tutorial describes the structure and function of the cancer-causing protein BCR-ABL. It also shows how drugs targeting this protein can help treat chronic myeloid leukemia (CML), a cancer of the white blood cells.
