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X Inactivation

Topic
  • Genetics
  • Gene Expression & Regulation
  • Epigenetics
  • Anatomy & Physiology
  • Reproduction & Development
Resource Type
  • Videos
  • Animations
Level
High School — AP/IBCollege
Duration
00:00:55
Favorited By
6 Users
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Description

This animation shows how X chromosomes are randomly switched off in most female mammals.

In most female mammals, one X chromosome is randomly inactivated to compensate for the fact that females have twice as many X-chromosome genes as males do. This phenomenon is called dosage compensation. About half the cells in these females express genes from the maternal X chromosome, and the other half express genes from the paternal X chromosome. The animation illustrates this phenomenon, called X inactivation, with an example from calico cats.

This animation is a clip from a 2003 Holiday Lecture Series, Learning From Patients: The Science of Medicine. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different steps in the inactivation process.

Details
Key Terms

Barr body, chromosome, dosage compensation, lyonization, mosaicism, sex linkage, tortoiseshell cat, X-linked trait

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History
Date Published 02.04.03
Materials
Large (MOV) 2 MB
Large (WMV) 2 MB
Small (MOV) 1 MB
Small (WMV) 1 MB
Transcript (PDF) 11 KB

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