Why Do Some People with the Sickle Cell Genotype Not Have Symptoms?

In this inquiry-based activity, students engage in science practices to figure out why some people with a genetic condition that usually leads to sickle cell disease do not have disease symptoms.

This activity is based on content covered in the Scientists at Work video A Genetic Treatment for Sickle Cell Disease. Instead of frontloading information from the film, the activity guides students through “figuring out” the key concepts first. As they investigate and make sense of the phenomenon, students engage in practices such as observing, questioning, and using and developing models.

The “Card Images” ZIP file contains individual image files for the cards used in this activity that can be used in the classroom, particularly in online courses. A document within the ZIP file contains suggestions for their use. These card images are licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) license. We would ask that you attribute these to BioInteractive and not use them for commercial purposes.

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