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Understanding Variation in Human Skin Color

Image from the activity showing skin color variation over a map

Topic

  • Genetics
  • Patterns of Inheritance
  • Anatomy & Physiology
  • Skin & Musculoskeletal System
  • Evolution
  • Human Evolution
  • Math & Computational Skills
  • Data Analysis

Resource Type

  • Activities
  • Lessons

Level

High School — GeneralHigh School — AP/IBCollege
Saved By
36 Users
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Description

In this activity, students extend the concepts covered in the short film The Biology of Skin Color through the application of models and mathematical thinking to explain how genomic variation and human ancestry can explain differences in skin color, a polygenic trait.

Humans living in different parts of the world have different natural skin colors. In this three-part activity, students learn how patterns in variations in several genes provide an explanation for differences in this trait. In Part 1 of this activity, a simple mathematical model illustrates an idealized relationship between the number of genes involved in a trait and the number of phenotypes that can occur from the combination of alleles. In Part 2, students learn about the methods geneticists use to identify skin color genes and to estimate heritability. Finally, in Part 3, students learn how geneticists analyze genetic variations to trace an individual’s ancestry. They then draw conclusions about the predominant ancestry of two different individuals by comparing their genetic profiles against real allele frequency data.

The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.

Student Learning Targets

  • Compare an individual’s DNA against a database of DNA sequences from different populations to infer ancestry. 
  • Develop mathematical models to explore how the number of genes that influence a trait affect the possible number of phenotypes. 
  • Use SNP data to evaluate and make evidence-based claims about the possible genetic ancestry of individuals.

Estimated Time

One 50-minute class period.

Key Terms

allele frequency, genotype, heritability, indigenous population, locus, phenotype, polygene, single nucleotide polymorphism (SNP)

Primary Literature

Klug, W.S., M.R. Cummings, and C.A. Spencer. Concepts of Genetics. 8th Edition. Pearson Education, Inc., Upper Saddle River, NJ. ISBN 0131918338, 2006.

Sturm, Richard A. and David L. Duffy. “Human pigmentation genes under environmental selection,” Genome Biology 13 (2012): 248. https://doi.org/10.1186/gb-2012-13-9-248.

Sturm, Richard A. “Molecular genetics of human pigmentation diversity,” Human Molecular Genetics 18 (2009): R9–R17. https://doi.org/10.1093/hmg/ddp003.

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History

Date Published 09.22.16
Date Updated 05.01.20

NGSS (2013)

HS-LS3-1, HS-LS3-3; SEP2, SEP4

AP Biology (2019)

SYI-3.B, IST-1.K, IST-1.P, IST-2.E; SP2, SP4, SP5, SP6

IB Biology (2016)

5.1, 5.2, B.5, C.1

Common Core (2010)

Math.A-CED.1, Math.S-IC.1; MP1, MP4, MP8

Vision and Change (2009)

CC3; DP1, DP3

Materials

Resource Google Folder (link)
Educator Materials (PDF) 1 MB
Student Handout (PDF) 1 MB
Educator Materials - Español (PDF) 1 MB
Student Handout - Español (PDF) 824 KB

Use This Resource With

Video Resource
The Biology of Skin Color

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