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Translation (Advanced Detail)

Topic
  • Biochemistry & Molecular Biology
  • Macromolecules
  • DNA & RNA
Resource Type
  • Videos
  • Animations
Level
High School — AP/IBCollege
Duration
00:03:04
Favorited By
9 Users
Share This
View in Spanish
Description

This animation shows the translation of messenger RNA into protein and details the interactions between the transfer RNA molecules and the ribosome. 

The ribosome is a molecular factory that translates the genetic information in messenger RNA (mRNA) into a string of amino acids (a polypeptide chain) that becomes a protein. The ribosome assembles around mRNA. Inside the ribosome, the nucleotide sequence of the mRNA is read three nucleotides at a time by transfer RNA (tRNA) molecules. When the three-nucleotide “code” of the mRNA, which is called a codon, matches a three-nucleotide code in the tRNA, which is called the anticodon, the tRNA binds and the amino acid carried by that particular tRNA is added to the growing polypeptide chain. The addition of each amino acid is a three-step cycle in which tRNA molecules interact with the ribosome at different sites. The polypeptide chain then folds into the three-dimensional structure of the protein.

This animation shows the translation process in three-dimensional detail, using the production of the hemoglobin protein as an example. Depending on students’ backgrounds, it may be helpful to pause the animation at various points to identify the molecules and describe their interactions.  

Details
Key Terms

amino acid, anticodon, central dogma, codon, gene expression, hemoglobin, mRNA, nucleic acid, protein, ribosome, tRNA

Terms of Use

The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.

Version History
Date Published 02.05.03
Date Updated 06.02.20
Curriculum Connections
NGSS (2013)

HS-LS1.A

AP Biology (2019)

IST-1

IB Biology (2016)

2.7, 7.3

Vision and Change (2009)

CC3

Materials
HD (M4V) 109 MB
HD (WMV) 92 MB
SD (M4V) 46 MB
SD (WMV) 47 MB
Transcript (PDF) 14 KB
Spanish Dub (Español) 374 MB
Transcript - Español (PDF) 161 KB

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