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Targeting Infected Cells for Immune Defense

Topic

  • Cell Biology
  • Cell Communication
  • Microbiology
  • Viruses
  • Anatomy & Physiology
  • Immune System

Resource Type

  • Videos
  • Animations

Level

High School — AP/IBCollege

Duration

00:02:34
Saved By
11 Users
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Description

This animation shows how a cell infected by a virus signals cytotoxic T cells to destroy itself.

In order to prevent a virus from spreading, cytotoxic T cells (also known as CTLs) identify and eliminate cells that have already been infected. The animation illustrates how infected cells cut up viral proteins and present the fragments, called antigens, on their surfaces using MHC class I molecules. When a cytotoxic T cell recognizes that the protein fragment is foreign in origin, it triggers the release of proteins that destroy the infected cell, preventing it from producing more viruses.

This animation is a clip from a 2007 Holiday Lecture Series, AIDS: Evolution of an Epidemic. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different proteins or structures.

 

Key Terms

antigen, CD8, cytotoxic T lymphocyte (CTL), granzyme, immune system, MHC class I, perforin, receptor, ubiquitin, virus

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

Video files meet criteria.

Version History

Date Published 02.05.07

Materials

Large (MOV) 11 MB
Large (WMV) 11 MB
Small (MOV) 5 MB
Small (WMV) 5 MB
Transcript (PDF) 14 KB

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