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Structure of Dengue Virus

Topic
  • Biochemistry & Molecular Biology
  • Macromolecules
  • Microbiology
  • Viruses
  • Pathogens & Disease
Resource Type
  • Videos
  • Animations
Level
High School — AP/IBCollege
Duration
00:01:03
Favorited By
2 Users
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Description

This animation zooms into a 3D model of dengue virus, moving from the virus’s outer structures to its inner core.

As shown in the animation, the outside of the dengue virus is made up of glycoproteins arranged in geometric patterns of two-, three-, and five-fold symmetry. These glycoproteins float over a lipid bilayer that covers the nucleocapsid, a protein core encasing the virus’s RNA genome.

This animation is a clip from a 2010 Holiday Lecture Series, Viral Outbreak: The Science of Emerging Disease. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different parts of the viral structure.

Details
Key Terms

capsid, envelope, glycoprotein, infectious disease, lipid, protein, RNA genome

Primary Literature

Kuhn, R. J., Wei Zhang, Michael G. Rossmann, Sergei V. Pletnev, Jeroen Corver, Edith Lenches, Christopher T. Jones, et al. “Structure of Dengue Virus: Implications for Flavivirus Organization, Maturation, and Fusion.” Cell 108, 5 (2002): 717–725. https://doi.org/10.1016/S0092-8674(02)00660-8. ​​​​​​

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History
Date Published 02.05.10
Materials
Large (MOV) 8 MB
Large (WMV) 8 MB
Small (MOV) 5 MB
Small (WMV) 5 MB
Transcript (PDF) 11 KB

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