Somatic Cell Nuclear Transfer (Schematic)
This animation shows how somatic cell nuclear transfer (SCNT) creates an embryo from an egg cell and a body cell.
During SCNT, scientists remove the nucleus from a healthy egg cell. They then transplant a nucleus from another cell into the egg cell. The resulting embryo can be used to create a cloned organism (reproductive cloning), or to generate embryonic stem cells that genetically match the nucleus donor (therapeutic cloning). The animation illustrates an example of cloning with a skin cell nucleus donor.
This animation is a clip from a 2006 Holiday Lecture Series, Potent Biology: Stem Cells, Cloning, and Regeneration. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different steps in the SCNT process.
blastocyst, cell division, cloning, embryo, embryonic stem cell, laboratory technique, nucleus, oocyte