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Description
This activity has been archived while we produce a more up-to-date version of this activity and the accompanying film. We are hoping the new activity and film will be available by the end of 2021.
This activity supports the short film Natural Selection in Humans about the connection between sickle cell disease and malaria. It allows students to further explore how scientists make their discoveries by building on research by other scientists.
Students read a passage about the decades of research on sickle cell disease (also known as sickle cell anemia), which was conducted prior to Anthony Allison’s work. Through a series of questions, students explore how Allison’s discovery was made possible by the work of others and how he was able to make the link between sickle cell disease and malaria.
The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.
Student Learning Targets
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Read and interpret textual information.
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Make claims based on evidence.
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Key Terms
allele, antimalarial drug, autosome, carrier, character, dominant, evolution, genotype, HbA, HbS, hemoglobin, heterozygote, homozygote, hypothesis, malaria, pedigree, phenotype, recessive, sickling
Terms of Use
The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.
Version History
NGSS (2013)
HS-LS3-1, HS-LS3-3, HS-LS4-2, HS-LS4-3; SEP1, SEP6
AP Biology (2019)
EVO-1.C, EVO-1.D, EVO-1.O, IST-1.I, IST-2.E, IST-4.A, IST-4.B, SYI-3.C, SYI-3.D; SP1, SP2, SP3
IB Biology (2016)
3.1, 3.4
AP Environmental Science (2020)
Topic(s): 2.6
Learning Objectives & Practices: ERT-2.H, SP1, SP3
IB Environmental Systems and Societies (2017)
3.2
Common Core (2010)
ELA.RST.9–12.2, ELA.RST.9–12.7
Vision and Change (2009)
CC1, CC3, CC5; DP1, DP6