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Role of p53 in Transcription

Topic

  • Biochemistry & Molecular Biology
  • Macromolecules
  • Genetics
  • Gene Expression & Regulation

Resource Type

  • Videos
  • Animations

Level

High School — AP/IBCollege

Duration

00:00:26
Saved By
4 Users
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Description

This animation shows how the p53 protein binds to DNA to initiate transcription.

p53 is a transcription factor, a protein that turns genes on. The animation illustrates how p53 recognizes and binds to a promoter, a specific region of DNA that initiates the transcription of the adjacent gene. After binding to the promoter, p53 recruits an RNA polymerase to transcribe the gene into mRNA.

This animation is a clip from a 2003 Holiday Lecture Series, Learning From Patients: The Science of Medicine. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different structures.

Key Terms

activator, binding site, DNA, messenger RNA (mRNA), promoter, RNA polymerase, transcription factor

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

Video files partially meet criteria.

Version History

Date Published 02.04.03

Materials

Large (MOV) 1 MB
Large (WMV) 1 MB
Small (MOV) 0.6 MB
Small (WMV) 0.6 MB
Transcript (PDF) 10 KB

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