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RNA Interference

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Computer image of DNA from the interactive

Topic

  • Biochemistry & Molecular Biology
  • DNA & RNA
  • Biotechnology
  • Genetics
  • Gene Expression & Regulation

Resource Type

  • Interactive Media
  • Click & Learn

Level

High School — AP/IBCollege
Saved By
13 Users
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Description

This tutorial describes how RNA interference was discovered, how it works, and potential applications to treating disease.

Scientists first described the process of RNA interference (RNAi), the silencing of gene expression by short double-stranded RNA molecules, in plants and worms. The process was then shown to occur in many animals. In this Click & Learn, students learn how the process works in cells and how scientists could use it to silence genes involved in disease.

The accompanying worksheet guides students’ exploration.

Student Learning Targets

Explain how RNA interference can be used to regulate gene expression.

Estimated Time

One 50-minute class period.

Key Terms

ATP, Caenorhabditis elegans, Dicer, double-stranded RNA (dsRNA), laboratory technique, messenger RNA (mRNA), petunia, RNAi, RNA-induced silencing complex (RISC), small interfering RNA (siRNA)

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History

Date Published 02.28.95

NGSS (2013)

HS-LS1-1, HS-LS3-1, HS-LS4-4; SEP6

AP Biology (2019)

IST-1.A, IST-1.N; SP1

IB Biology (2016)

2.7, 7.2

Common Core (2010)

ELA.RST.9-12.2, ELA.WHST.9-12.9

Vision and Change (2009)

CC2; DP1

Materials

Worksheet (PDF) 139 KB

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