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Pelvic Evolution in Sticklebacks

Topic
  • Genetics
  • Gene Expression & Regulation
  • Bioinformatics
  • Evolution
  • Natural Selection
  • Science Practices
  • Graph Interpretation
Resource Type
  • Activities
  • Data Points
Level
High School — GeneralHigh School — AP/IBCollege
Favorited By
6 Users
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Description

This activity guides the analysis of a published scientific figure from a study that used SNP genotyping to identify the mutations that result in morphological differences in stickleback fish.

Threespine stickleback fish from marine populations usually have a pelvis with protective spines. Some freshwater sticklebacks, however, either partially or completely lack a pelvis. In this study, scientists investigated the mutations behind these morphological differences using SNP genotyping. Panel A of the figure shows SNP genotyping results for nine stickleback populations with reduced or absent pelvises. The scientists used these data to estimate the locations of deletion mutations in each population. Panel B shows the sources of each population.

The “Educator Materials” document includes a captioned figure, background information, graph interpretation, and discussion questions. The “Student Handout” includes a captioned figure and background information.

Student Learning Targets
  • Analyze and interpret data from a scientific figure. 
  • Describe how genotyping techniques can be used to identify genes associated with certain traits.
  • Describe how changes in genotype, such as deletion mutations, can lead to change in phenotype.
Details
Estimated Time
Within one 50-minute class period.
Key Terms

body morphology, DNA sequence deletion, enhancer, gene map, mutation, noncoding region, pituitary homeobox transcription factor 1 (Pitx1), single nucleotide polymorphism (SNP), SNP genotyping

Primary Literature

Chan, Yingguang F., Melissa E. Marks, Felicity C. Jones, Guadalupe Villarreal Jr., Michael D. Shapiro, Shannon D. Brady, Audrey M. Southwick, et al. “Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer.” Science 327, 5963 (2010): 302–305. https://doi.org/10.1126/science.1182213. 
 
To access this article, set up a free AAAS account. An annotated version of the article is also available from Science in the Classroom.

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level

The documents for this resource meet accessibility standards in accordance with the final rule for Section 508 of the National Rehabilitation Act.
Version History
Date Published 04.09.18
Date Updated 04.09.18
Curriculum Connections
NGSS (2013)

HS-LS4-1, HS-LS4-2, HS-LS4-4, HS-LS3-1; SEP2, SEP4, SEP5

AP Biology (2019)

EVO-1.H, EVO-1.J, EVO-1.N, IST-1.J; SP1, SP2, SP4

IB Biology (2016)

4.1, 5.4

Common Core (2010)

ELA.RST.9-12.7
Math.S-IC.1; MP2, MP5

Vision and Change (2009)

CC1, CC3; DP2, DP3

Materials
Educator Materials (PDF) 495 KB
Student Handout (PDF) 350 KB
Supplemental Images (PDF) 218 KB

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