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Monkey Social Status and Immune Response

Topic
  • Genetics
  • Gene Expression & Regulation
  • Anatomy & Physiology
  • Immune System
  • Animal Behavior
  • Science Practices
  • Graph Interpretation
Resource Type
  • Activities
  • Data Points
Level
High School — GeneralHigh School — AP/IBCollege
Favorited By
7 Users
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Description

This activity guides the analysis of a published scientific figure from a study on how social status affects the expression of genes involved in immune system processes.

Lower social status often has negative effects on the health and survival of primates. In this study, scientists explored how gene expression levels varied among female rhesus macaque monkeys of different social ranks. The figure shows expression levels for the gene IL8RB, which is involved in the inflammatory immune response, for macaques of different ranks. A dominance ranking of 1 represents the highest social rank, and a dominance ranking of 5 the lowest. The “Educator Materials” document includes a captioned figure, background information, graph interpretation, and discussion questions. The “Student Handout” includes a captioned figure and background information.

Student Learning Targets
  • Analyze and interpret data from a scientific figure. 
  • Compare gene expression data from different groups of individuals in a population.
Details
Estimated Time
Within one 50-minute class period.
Key Terms

box-and-whisker plot, dominance, gene expression, IL8RB (interleukin 8 receptor, beta), immune system, inflammation, p value, social rank, trend line, white blood cell

Primary Literature

Tung, Jenny, Luis B. Barreiro, Zachary P. Johnson, Kasper D. Hansen, Vasiliki Michopoulos, Donna Toufexis, Katelyn Michelini, et al. “Social environment is associated with gene regulatory variation in the rhesus macaque immune system.” Proceedings of the National Academy of Sciences 109, 17 (2012): 6490–6495. http://doi.org/10.1073/pnas.1202734109.

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level

The documents for this resource meet accessibility standards in accordance with the final rule for Section 508 of the National Rehabilitation Act.
Version History
Date Published 03.12.18
Date Updated 03.12.18
Curriculum Connections
NGSS (2013)

HS-LS2-8; SEP2, SEP4, SEP5

AP Biology (2019)

IST-2.A, IST-3.A, ENE-3.D; SP1, SP4

IB Biology (2016)

2.4, 3.1, B.4

Common Core (2010)

ELA.RST.9-12.7
Math.S-ID.3, Math.S-IC.1; MP2, MP5

Vision and Change (2009)

CC3; DP2, DP3

Materials
Educator Materials (PDF) 931 KB
Student Handout (PDF) 1 MB

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