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Modeling the Structure of DNA

Screenshot displaying a section of paper DNA double helix

Topic

  • Biochemistry & Molecular Biology
  • Macromolecules
  • DNA & RNA
  • Scientific Skills & Literacy
  • Visual & Physical Models

Resource Type

  • Activities
  • Labs & Demos

Level

High School — AP/IBCollege
Saved By
57 Users
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View in Spanish

Description

In this activity, students build a paper model of DNA and use their model to explore key structural features of the DNA double helix. This activity can be used to complement the short film The Double Helix.

Students use paper nucleotides printed on card stock to build a single-stranded DNA sequence assigned by their instructor. They then use the rules of base complementarity to construct a second strand and generate a three-dimensional double helix. Through building and observing this model, students explore the basic structure of phosphodiester bonds, base pairs, the spatial relationships among the components of nucleotides in DNA, and the antiparallel nature of the double helix. Written and video instructions describe each step of the model-building process.

You can download six videos (bundled as a ZIP file) to see how to build the DNA model, or you can stream them from YouTube via the links below:

  • Paper DNA Model: Part 1: Preparing the Nucleotides
  • Paper DNA Model: Part 2: Folding the Nucleotides
  • Paper DNA Model: Part 3: Making a Strand of DNA
  • Paper DNA Model: Part 4: Practicing Base-Pairing
  • Paper DNA Model: Part 5: Building a Double Helix
  • Paper DNA Model: Part 6: Expanding the Helix

The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.

Student Learning Targets

  • Build a physical model of the DNA double helix.
  • Use a model of DNA to explore and describe key structural features of the molecule.
     

Estimated Time

One to two 50-minute class periods, depending on the amount of work assigned as homework.

Key Terms

deoxyribose, double helix, genetics, model, nitrogenous base, nucleotide, phosphate, phosphodiester bond

Primary Literature

Franklin, Rosalind E. and R. G. Gosling. “Molecular Configuration in Sodium Thymonucleate.” Nature 171, 4356 (1953): 740–741. https://doi.org/10.1038/171740a0. 

Watson, J. D. and F. H. C. Crick. “Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid.” Nature 171, 4356 (1953): 737–738. https://doi.org/10.1038/171737a0. 

Wilkins, M. H. F., A. R. Stokes, and H. R. Wilson. “Molecular Structure of Nucleic Acids: Molecular Structure of Deoxypentose Nucleic Acids.” Nature 171, 4356 (1953): 738–740. https://doi.org/10.1038/171738a0.

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

PDF files meet criteria. Video files partially meet criteria. Spanish files meet criteria.

Version History

Date Published 11.07.19
Date Updated 10.04.21

NGSS (2013)

HS-LS3-1

AP Biology (2019)

IST-1.K, IST-1.L, IST-1.M, SYI-1.B; SP2

IB Biology (2016)

2.6, 7.1

Common Core (2010)

ELA.RST.9–12.3

Vision and Change (2009)

CC2

Materials

Download Resource Google Folder (Link)
Download Educator Materials (PDF) 761 KB
Download Student Handout (PDF) 4 MB
Download Paper Nucleotides Sheet (JPG) 170 KB
Download Video Instructions (ZIP) 252 MB
Download Educator Materials - Español (PDF) 732 KB
Download Student Handout - Español (PDF) 4 MB
Download Video Instructions - Español (ZIP)

Additional Materials

  • two copies of the paper nucleotides sheet, printed on heavy card stock, per student
  • scissors
  • colored pencils, markers, or crayons
  • ruler
  • access to the video instructions (optional, but recommended)
     

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