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Mismatch Repair

Topic

  • Biochemistry & Molecular Biology
  • DNA & RNA
  • Genetics
  • Mutations

Resource Type

  • Videos
  • Animations

Level

High School — GeneralHigh School — AP/IBCollege

Duration

00:01:22
Saved By
10 Users
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Description

This animation shows how mistakes made during DNA replication are repaired by the cell.

Replication mistakes may occur as DNA polymerase copies the DNA strands. One type of mistake, called a mismatch, happens when the polymerase incorporates the wrong nucleotide into a strand. The animation illustrates how mismatches can be fixed with a set of repair proteins. These proteins recruit an enzyme called EXO1 to remove the incorrect section. DNA polymerase then replaces the removed section with the correct nucleotides.

This animation is a clip from a 2003 Holiday Lecture Series, Learning From Patients: The Science of Medicine. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different structures or proteins.

Key Terms

DNA polymerase, enzyme, exonuclease 1 (EXO1), mutation, nucleic acid, nucleotide, replication

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

Video files meet criteria.

Version History

Date Published 02.04.03

Materials

Large (MOV) 4 MB
Large (WMV) 4 MB
Small (MOV) 3 MB
Small (WMV) 3 MB
Transcript (PDF) 13 KB

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