This activity has been archived while we produce a more up-to-date version of this activity and the accompanying film. We are hoping the new activity and film will be available by the end of 2021.

In this activity, students apply concepts pertaining to the genetics of sickle cell disease and its relationship to malaria explored in the short film The Making of the Fittest: Natural Selection in Humans.

Students work through questions and problems in three sections: Mendelian genetics and probability, pedigrees, and chi-square statistics. Within each section, the questions sequentially move from a more basic to a more advanced level to develop students’ skills.

The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.