Mendelian Genetics, Probability, Pedigrees, and Chi-Square Statistics
In this activity, students apply concepts pertaining to the genetics of sickle cell disease and its relationship to malaria explored in the short film The Making of the Fittest: Natural Selection in Humans.
Students work through questions and problems in three sections: Mendelian genetics and probability, pedigrees, and chi-square statistics. Within each section, the questions sequentially move from a more basic to a more advanced level to develop students’ skills.
Student Learning Targets
- Use Punnett squares to predict the frequencies of genotypes in the offspring based on the genotypes of the parents.
- Analyze pedigrees to deduce genotypes, phenotypes, and probabilities, and use the rules of probability as they relate to genetics problems.
- Use the chi-square statistical analysis test to determine the significance of genetics data.
codominance, dominant trait, genotype, hemoglobin, heterozygote, homozygote, incomplete dominance, independent assortment, phenotype, recessive trait, sickle cell anemia
The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.
HS-LS3-1, HS-LS3-3, HS-LS4-3; SEP2, SEP4, SEP5
EVO-1.E, EVO-1.O, IST-1.I, IST-2.E, IST-4.A, IST-4.B, SYI-3.C; SP1, SP2, SP4, SP5
3.1, 3.4, 10.2
Math.A-REI.3, Math.S-CP.2, Math.S-IC.2; MP2, MP4
CC3; DP2, DP3, DP6