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How a Salmonella Infection Begins

Topic

  • Microbiology
  • Bacteria
  • Pathogens & Disease

Resource Type

  • Videos
  • Animations

Level

High School — GeneralHigh School — AP/IBCollege

Duration

00:01:19
Saved By
13 Users
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Description

This animation shows how pathogenic Salmonella bacteria invade intestinal cells and evade the immune system.

Pathogenic strains of Salmonella can cause diseases, such as typhoid fever and diarrhea, in humans. The animation illustrates how a pathogenic Salmonella bacterium invades and survives inside a human intestinal epithelial cell.

As shown, the bacterium uses a syringe-like mechanism, called the Type III secretion system, to inject bacterial proteins into the host cell. These proteins cause the host cell to take in the bacterium in a vacuole. The bacterium releases more proteins to alter the structure of the vacuole, which protects it against lysosomes. Now safe from the immune system, the bacterium can multiply and infect other cells.

This animation is a clip from a 1999 Holiday Lecture Series, 2000 and Beyond: Confronting the Microbe Menace. Depending on students’ background, it may be helpful to pause the animation at various points to discuss different features.

Key Terms

diarrhea, host cell, infectious disease, intestines, intracellular pathogen, lysosome, salmonellosis, typhoid fever, vacuole

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

Video files meet criteria.

Version History

Date Published 02.04.99

Materials

Large (MOV) 5 MB
Large (WMV) 5 MB
Small (MOV) 2 MB
Small (WMV) 2 MB
Transcript (PDF) 13 KB

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