Skip to main content
Toggle User Menu

HHMI BioInteractive

  • Español
  • Search
  • Log In/Create Account
  • Classroom Resources
  • Planning Tools
  • Professional Development
  • About Us

Gleevec-Resistant BCR-ABL

Launch Interactive
Topic
  • Biochemistry & Molecular Biology
  • Macromolecules
  • Science Practices
  • Models & Simulations
Resource Type
  • Interactive Media
  • 3D Models
Level
High School — GeneralHigh School — AP/IBCollege
Share This
View in Spanish
Description

This model shows a mutated form of the cancer-causing protein BCR-ABL that is resistant to the drug Gleevec.

Gleevec is a drug for treating chronic myeloid leukemia (CML), a cancer of white blood cells. In CML, white blood cells divide uncontrollably due to an overactive tyrosine kinase protein called BCR-ABL. Although Gleevec usually blocks the activity of BCR-ABL, it is unable to bind to the mutant form of BCR-ABL shown in this model. The model shows the ABL kinase domain of the mutant protein, which includes a binding site for ATP.

The 3D model can be viewed and rotated in the online 3D Viewer. The accompanying downloads provide other ways to display and interact with the model. The “3D Preview” contains an image of the model that can be viewed and rotated within Adobe Acrobat. The “3D Movie Loop” is a short looping animation that shows the model being rotated. The “3D Printing Data” STL file allows the model to be printed on a 3D printer.

Note that the STL file can be viewed with the free MakerWare software from MakerBot, but MakerWare will print only to a MakerBot printer. Please use the software provided with your 3D printer to print the STL file.

Details
Key Terms

cancer, dasatinib, Gleevec, health care, imatinib, medicine, mutation, protein, resistance, tyrosine kinase

Terms of Use

The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.

Version History
Date Published 05.23.14
Materials
3D Printing Data (STL) 38 MB
3D Image (PDF) 15 MB
3D Animation (MP4) 6.7 MB

Explore Related Content

Other Resources About BCR-ABL
Showing of
3D Models
BCR-ABL
3D Models
Adenosine Triphosphate (ATP)
3D Models
Gleevec (Imatinib)
3D Models
Dasatinib
Click & Learn
BCR-ABL: Protein Structure and Function
Animations
Mechanism of a Medication for Chronic Myeloid Leukemia
Animations
Resistance to a Medication for Chronic Myeloid Leukemia
Other Resources About Cancer
Showing of
3D Models
BCR-ABL
3D Models
Adenosine Triphosphate (ATP)
3D Models
Gleevec (Imatinib)
3D Models
Dasatinib
Clips
Mutations in Cancer
Card Activities
Classifying Cancer Genes and Examining Patient Data
Click & Learn
BCR-ABL: Protein Structure and Function
Illustration of the phases of the cell cycle
Click & Learn
The Eukaryotic Cell Cycle and Cancer
Data Points
Efficacy of a Medication for Chronic Myeloid Leukemia
Data Points
Cell Division and Cancer Risk
Other Related Resources
Showing of
3D Models
BCR-ABL
3D Models
Adenosine Triphosphate (ATP)
Screenshot displaying a section of paper DNA double helix
Labs & Demos
Modeling the Structure of DNA
Animations
Role of p53 in Transcription
Animations
The Mammalian Biological Clock
Animations
How DNA Is Packaged
Animations
Translation (Basic Detail)
Animations
Translation (Advanced Detail)
Animations
The Fate of Fat
Click & Learn
Molecular Structure of Fat

HHMI BioInteractive

  • Facebook
  • Instagram
  • Twitter
  • YouTube
  • Newsletter Signup
  • HHMI.org
  • Terms of Use
  • Privacy Policy