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A Genetic Treatment for Sickle Cell Disease

Topic

  • Genetics
  • Patterns of Inheritance
  • Gene Expression & Regulation
  • Genetic Disease

Resource Type

  • Videos
  • Scientists at Work

Level

High School — GeneralHigh School — AP/IBCollege

Duration

00:05:47
Saved By
8 Users
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Description

This video presents an intriguing phenomenon: two patients who carry the same genetic variation, which is known to cause sickle cell disease, have very different outcomes.

One patient has debilitating pain crises that have kept her from attending college, and the other does not have symptoms. What could be the difference? The answer has to do with the expression of a certain gene. This discovery could lead to a new treatment for sickle cell disease.

This video can be used as part of a lesson about genetic variations, inheritance, genetic medicine, and/or gene expression. 

An audio descriptive version of the film is available via our media player.

Key Terms

allele, fetal hemoglobin, gene switch, genetic medicine, HBB, mutation, recessive, red blood cell, variation

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

PDF files meet criteria. Video files meet criteria.

Version History

Date Published 08.30.22

NGSS (2013)

HS-LS1.A, HS-LS3.A

AP Biology (2019)

 IST-1.I, IST-1.N, IST-2.D

IB Biology (2016)

 2.7, 3.4

Vision and Change (2009)

CC2

Materials

Resource Google Folder (link)
1080p (M4V) 225 MB
1080p (WMV) 347 MB
720p (M4V) 94 MB
720p (WMV) 158 MB
Transcript (PDF) 201 KB

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