Genetic Mutations and Disease

This interactive module explores how mutations arise in germline and somatic cells. It also shows how these mutations can lead to genetic conditions, such as cystic fibrosis and cancer.

Whether a mutation causes disease depends on multiple factors, including the mutation’s location in the genome, the type of cell in which it is located, and how early in life it occurs. For example, mutations that occur earlier in development usually affect a greater portion of the body. This Click & Learn illustrates how two cell lineages (germline and somatic) are generated during development and that mutations can occur in either lineage. Students explore the effects of mutations in each lineage with examples of real genetic diseases.

The “Poster” PDF provides an accessible version of the content in this Click & Learn.