The Eukaryotic Cell Cycle and Cancer
This interactive module explores the phases, checkpoints, and protein regulators of the cell cycle. The module also shows how mutations in genes that encode cell cycle regulators can lead to the development of cancer.
Students can toggle between two different views of the cell cycle by pressing the text in the center of the graphic. The “Cell Cycle Phases” view describes the cell cycle phases and checkpoints, and includes illustrations of the cell’s chromosomes. This view is appropriate for all levels of high school biology. The “Cell Cycle Regulators and Cancer” view explains the protein regulators, their roles in cell cycle progression, and how mutated versions can lead to cancer. This view may be more appropriate for AP/IB Biology and introductory college biology.
The accompanying worksheets guide students’ exploration. The “Overview Worksheet” is intended to provide an introduction to the cell cycle as it relates to cancer. For a more comprehensive review of the cell cycle and the molecules that regulate each phase, use the “In-Depth Worksheet.”
Student Learning Targets
- Explain the importance of mitosis and cell death during development, growth, and repair of the human body.
- Describe the phases of the cell cycle and what happens in each phase.
- Explain the relationship between cancer and the cell cycle.
anaphase-promoting complex (APC/C), cell division, checkpoint, cyclin-dependent kinase (CDK), gap phase, mitosis, oncogene, p53, synthesis phase, tumor suppressor
HS-LS1-4, HS-LS3-2; SEP2, SEP6
2.E.1, 3.A.2, 3.B.2, 3.D.4; SP1, SP6
CC2; DP1, DP3