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Teaching Viruses and Epidemiology Online
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5. Ebola Disease Detectives
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Ebola: Disease Detectives

Image from the activity of a DNA sequence

Topic

  • Biochemistry & Molecular Biology
  • Biotechnology
  • Microbiology
  • Viruses
  • Pathogens & Disease
  • Evolution
  • Phylogeny

Resource Type

  • Activities
  • Card Activities

Level

High School — GeneralHigh School — AP/IBCollege
Used In
1 BioInteractive Playlists
Saved By
51 Users
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Description

This hands-on activity allows students to analyze DNA sequences of Ebola viruses. Students use these sequences to track the virus’s spread during the 2013–2016 Ebola outbreak in West Africa.

After watching a related video, students sort strips of paper showing sequences from Ebola viruses isolated from infected patients from Sierra Leone. Students sort these sequences into groups based on similarities. Based on the groupings, students make claims about the evolution and transmission history of the virus. Students then compare their results to those of scientists who followed a similar procedure at the beginning of the outbreak. As an extension, students may analyze a Click & Learn about viruses that shows a 3-dimensional model and cross section of the Ebola virus.

The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.

Student Learning Targets

  • Analyze and interpret sequence data to explain how viruses evolve over time during an outbreak.
  • Develop visual representations of findings and conclusions.
     

Estimated Time

One 50-minute class period, with additional time for watching the video.

Key Terms

adaptation, DNA sequence, evolution, mutation, outbreak, public health, virus

Primary Literature

Gire, S. K., A. Goba, K.G. Andersen, R.S. Sealfon, D.J. Park, L. Kanneh, S. Jalloh, et al. “Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.” Science 345, 6202 (2014): 1369–1372. https://doi.org/10.1126/science.1259657.

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History

Date Published 12.14.16
Date Updated 04.30.20

NGSS (2013)

HS-LS3-2; SEP2, SEP4, SEP6

AP Biology (2019)

EVO-1.C, EVO-1.O, IST-1.A, IST-1.L, IST-1.O, IST-4.A, IST-4.B, SYI-3.D; SP2, SP3, SP4

IB Biology (2016)

3.1, B.4

Vision and Change (2009)

CC3, CC5; DP1, DP3, DP6

Materials

Resource Google Folder (link)
Student Worksheet (PDF) 975 KB
Educator Materials (PDF) 942 KB
Introduction to Ebola (PDF) 534 KB
Sequence Sheet (PDF) 939 KB
Student Worksheet - Español (PDF) 497 KB
Educator Materials - Español (PDF) 243 KB
Introduction to Ebola - Español (PDF) 161 KB
Sequence Sheet - Español (PDF) 125 KB

Use This Resource With

Video Resource
Think Like a Scientist: Natural Selection in an Outbreak
Interactive Media Resource
Virus Explorer

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This Resource Appears in the Following Playlists

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Teaching Viruses and Epidemiology Online
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