This model shows the structure of the cancer drug dasatinib, which is used to treat chronic myeloid leukemia (CML).

Chronic myeloid leukemia (CML) is a cancer of white blood cells. In CML, white blood cells divide uncontrollably due to an overactive tyrosine kinase protein called BCR-ABL. Small-molecule drugs such as Gleevec (imatinib) and dasatinib compete with ATP for binding to a site on BCR-ABL, and prevent the kinase from signaling the division of more white blood cells. Gleevec is unable to bind to a particular mutant form of BCR-ABL. Dasatinib binds to this mutant form and is used to treat patients with Gleevec-resistant CML.

The 3D model can be viewed and rotated in the online 3D Viewer. The accompanying downloads provide other ways to display and interact with the model. The “3D Preview” contains an image of the model that can be viewed and rotated within Adobe Acrobat. The “3D Movie Loop” is a short looping animation that shows the model being rotated. The “3D Printing Data” STL file allows the model to be printed on a 3D printer.

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