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Cystic Fibrosis Mechanism and Treatment

Topic

  • Biochemistry & Molecular Biology
  • Macromolecules
  • Genetics
  • Genetic Disease
  • Cell Biology
  • Cell Structure & Function

Resource Type

  • Videos
  • Animations

Level

High School — GeneralHigh School — AP/IBCollege

Duration

00:02:31
Saved By
27 Users
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View in Spanish

Description

This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.

Cystic fibrosis is an autosomal recessive disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is an ion channel protein that transports chloride ions across the membranes of cells that line airways, glands, and the digestive tract. This animation illustrates how cystic fibrosis mutations can prevent CFTR from functioning properly, leading to the production of a thick mucus that obstructs airways and promotes infections. After screening hundreds of thousands of small molecules, scientists have identified a drug that can improve CFTR function and treat the disease in some patients.

Depending on students’ background, it may be helpful to pause the animation at various points to discuss different structures or molecules.

Key Terms

cystic fibrosis transmembrane conductance regulator (CFTR), drug, health care, ion channel, lungs, medicine, mucus, mutation

Terms of Use

The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.

Accessibility Level (WCAG compliance)

Video files meet criteria.

Version History

Date Published 04.19.18
Date Updated 04.27.22

Materials

HD (M4V) 93.6 MB
HD (WMV) 78.7 MB
SD (M4V) 21.2 MB
SD (WMV) 21.3 MB
Transcript (PDF) 151 KB
Spanish dub (MP4) 41 MB
Transcript - Español (PDF) 178 KB

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