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CRISPR-Cas9 Mechanism & Applications

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Image of the CRISPR Cas9 molecules from the interactive

Topic

  • Biochemistry & Molecular Biology
  • DNA & RNA
  • Biotechnology
  • Genetics
  • Gene Expression & Regulation
  • Genetic Disease

Resource Type

  • Interactive Media
  • Click & Learn

Level

High School — GeneralHigh School — AP/IBCollege
Used In
4 BioInteractive Playlists
Saved By
89 Users
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View in Spanish

Description

This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research.

Since it was first described in 2012, CRISPR-Cas9 (often shortened to “CRISPR”) has generated much interest and excitement. This Click & Learn allows students to explore and learn about a biotechnology tool that is at the forefront of scientific research and hear directly from leading scientists about how they use CRISPR. The Click & Learn comprises a self-paced interactive animation and a series of short videos of various scientists who are using CRISPR-Cas9 technologies for basic research, medical, and agricultural applications.

The “Web Assets” ZIP file contains the full animation and a set of related images and GIFs for use on social media, in the classroom, and for presentations to the public. Please credit HHMI BioInteractive if you use them.

Estimated Time

One to two 50-minute class periods.

Key Terms

base pairing, cleavage, complementary sequence, DNA repair, enzyme, guide RNA, homology-directed repair (HDR), laboratory technique, nonhomologous end joining (NHEJ), nuclease

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Accessibility Level (WCAG compliance)

Interactive media meets criteria.

Version History

Date Published 04.11.18
Date Updated 02.07.23

NGSS (2013)

HS-LS1.A, HS-LS3.A

AP Biology (2019)

IST-1.K, IST-1.L, IST-1.P, IST-2.A, IST-2.E, IST-4.B

IB Biology (2016)

2.6, 2.7, 3.5, 7.2, B.4, B.5

VIsion and Change (2009)

CC2, CC3

Materials

Web Assets (ZIP) 115 MB
Desktop App - macOS 10.10 or later, 64-bit (ZIP) 423 MB
Desktop App - Windows 7 or later, 64-bit (ZIP) 422 MB
iOS App - iPad and iPhone (Link) 251 MB

Related Science News

Science Says: Gene editing widely used in range of research
Chinese researcher claims first gene-edited babies

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Using CRISPR to Identify the Functions of Butterfly Genes
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Winging It: Analyzing a Scientific Paper
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Central Dogma and Genetic Medicine

Other Related Resources

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Illustration of RNA translation
Click & Learn
Central Dogma and Genetic Medicine
Illustration of DNA transcription from the activity
Card Activities
“Fixing” Gene Expression
Computer image of DNA from the interactive
Click & Learn
RNA Interference
Computer model of DNA replication
Animations
Trinucleotide Repeat
Image from the interactive
Click & Learn
Visualizing Gene-Expression Patterns
Illustration of DNA from the video
Animations
Seeing Single Molecules Move
Computer image of DNA
Animations
Polymerase Chain Reaction (PCR)
Image from the video showing RNA as a strip of paper
Animations
RNA Splicing
Computer image of regulation from the video
Animations
Regulation of Eukaryotic DNA Transcription
Image illustrating heterozygosity from the film
Film Activities
Activity for Genes as Medicine

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