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Teaching the Central Dogma Using the Rock Pocket Mouse and Genetic Medicine
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6. CRISPRCas9 Mechanism Applications
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CRISPR-Cas9 Mechanism & Applications

Launch Interactive
Topic
  • Biochemistry & Molecular Biology
  • DNA & RNA
  • Biotechnology
  • Genetics
  • Gene Expression & Regulation
  • Genetic Disease
Resource Type
  • Interactive Media
  • Click & Learn
Level
High School — GeneralHigh School — AP/IBCollege
Used In
4 BioInteractive Playlists
Favorited By
48 Users
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Description

This interactive module explores how CRISPR-Cas9 technology works and the many ways in which scientists are using it in their research.

Since it was first described in 2012, CRISPR-Cas9 (often shortened to “CRISPR”) has generated much interest and excitement. This Click & Learn allows students to explore and learn about a biotechnology tool that is at the forefront of scientific research and hear directly from leading scientists about how they use CRISPR. The Click & Learn comprises a self-paced interactive animation and a series of short videos of various scientists who are using CRISPR-Cas9 technologies for basic research, medical, and agricultural applications.

The “Web Assets” ZIP file contains the full animation and a set of related images and GIFs for use on social media, in the classroom, and for presentations to the public. Please credit HHMI BioInteractive if you use them.

Details
Estimated Time
One to two 50-minute class periods.
Key Terms

base pairing, cleavage, complementary sequence, DNA repair, enzyme, guide RNA, homology-directed repair (HDR), laboratory technique, nonhomologous end joining (NHEJ), nuclease

Terms of Use

Please see the Terms of Use for information on how this resource can be used.

Version History
Date Published 04.11.18
Date Updated 01.07.19
Curriculum Connections
NGSS (2013)

HS-LS1.A, HS-LS3.A

AP Biology (2019)

IST-1.K, IST-1.L, IST-1.P, IST-2.A, IST-2.E, IST-4.B

IB Biology (2016)

2.6, 2.7, 3.5, 7.2, B.4, B.5

VIsion and Change (2009)

CC2, CC3

Materials
Web Assets (ZIP) 115 MB
Desktop App - macOS 10.10 or later, 64-bit (ZIP) 423 MB
Desktop App - Windows 7 or later, 64-bit (ZIP) 422 MB
iOS App - iPad and iPhone (Link) 251 MB
Related Science News
Science Says: Gene editing widely used in range of research
Chinese researcher claims first gene-edited babies
Mutation that protects against HIV raises death rate
A gene-editing first: scientists tried CRISPR to fight HIV
Doctors try CRISPR gene editing for cancer, a 1st in the US
Doctors try 1st CRISPR editing in the body for blindness

Explore Related Content

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Using CRISPR to Identify the Functions of Butterfly Genes
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Winging It: Analyzing a Scientific Paper
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Regulation of Eukaryotic DNA Transcription
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RNA Splicing
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Genes as Medicine
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