In this hands-on activity, students build a paper model to explore how CRISPR-Cas9 is used to edit genes.

CRISPR-Cas9, commonly referred to as just CRISPR, is often mentioned in the news for its potential to treat genetic diseases. In this activity, students explore and learn about this biotechnology tool by building a two-dimensional paper model of the CRISPR system. They then apply their knowledge of complementary base pairing to model how CRISPR targets specific DNA sequences. Students are asked to compare their paper model to an online three-dimensional model. In an optional extension, students watch and reflect on videos of scientists explaining how they use CRISPR in their research.

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