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Analyzing Pedigrees

A pedigree showing a partner relationship between two individuals with three offspring, two of which are twins.

Topic

  • Science Practices
    • Explanations & Argumentation
  • Genetics
    • Patterns of Inheritance
    • Genetic Disease

Resource Type

  • Activities
    • Lessons

Level

High School — AP/IBCollege
Saved By
15 Members

Description

In this activity, students interpret several pedigrees of autosomal dominant and recessive conditions and consider the benefits and limitations of genetic testing.

Students answer multiple-choice questions about these pedigrees and explain their reasoning. For some questions, the goal is not to get the “right” answer but rather to discuss how pedigrees can be used to make decisions about one’s health. Students can answer questions as a class, in small groups or individually.

You can share the pedigree images via the “Student Handout” or “Slide Deck” presentation. The “Educator Materials” provides suggestions for implementing the activity and guiding discussion. A separate “Additional Background” document provides more information about pedigree symbols and other notations.

The “Resource Google Folder” link directs to a Google Drive folder of resource documents in the Google Docs format. Not all downloadable documents for the resource may be available in this format. The Google Drive folder is set as “View Only”; to save a copy of a document in this folder to your Google Drive, open that document, then select File → “Make a copy.” These documents can be copied, modified, and distributed online following the Terms of Use listed in the “Details” section below, including crediting BioInteractive.

Student Learning Targets

  • Interpret data in pedigrees of monogenic autosomal traits.
  • Apply the information in a pedigree to predict health outcomes and make decisions about genetic testing.
  • Consider the potential benefits and limitations of genetic testing for inherited diseases.

Estimated Time

One 50-minute class period.

Key Terms

BRCA1, breast cancer, carrier, dominant, genetic counseling, heterozygous, homozygous, recessive, spinocerebellar ataxia 1 (SCA1), thalassemia, variant

Primary Literature

Bennett, Robin L., Kathryn Steinhaus French, Robert G. Resta, and Jehannine Austin. 2022. “Practice resource‐focused revision: Standardized pedigree nomenclature update centered on sex and gender inclusivity: A practice resource of the National Society of Genetic Counselors.” Journal of Genetic Counseling 31, 6: 1238–1248. https://doi.org/10.1002/jgc4.1621.

Terms of Use

The resource is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license. No rights are granted to use HHMI’s or BioInteractive’s names or logos independent from this Resource or in any derivative works.

Accessibility Level (WCAG compliance)

PDF files meet criteria. Other file types meet criteria.

Version History

Date Published 08.31.23

NGSS 2013

HS-LS3-2, HS-LS3-3; SEP2, SEP6

AP Biology 2019

IST-1.I, IST-4.A; SP1, SP2

IB Biology 2016

3.4, 10.2

Common Core 2010

ELA.RST.9–12.7, ELA.WHST.9–12.1

Vision and Change 2009

CC3; DP2, DP6

Materials

Download Resource Google Folder (Link)
Download Educator Materials (PDF) 597 KB
Download Student Handout (PDF) 638 KB
Download Additional Background (PDF) 407 KB
Download Slide Deck (PPTX) 2 MB

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